Ben Stokes returned to the England XI, in place of Joe Root. Siddarth Kaul replaced an injured Bhuvneshwar Kumar while Deepak Chahar made his T20I debut, in place of Kuldeep Yadav as India opted to bowl.
Jason Roy and Jos Buttler helped England off to a blazing start, scoring 73 in the powerplay.
Jason Roy took only 23 deliveries to bring up his half-century.
India made inroads after a 94-run opening stand.
Hardik Pandya picked up quick wickets to stall England's progress.
Useful contributions from Jonny Bairstow and Ben Stokes helped England forward.
MS Dhoni effected a run out and took five catches, a record in T20Is, as England finished with 198 for 9.
Shikhar Dhawan fell early in the chase, getting out to David Willey in the third over.
Positive batting by Rohit Sharma and KL Rahul helped India score 70 in the powerplay.
Following the dismissal of KL Rahul, Rohit Sharma registered a brisk half-century and was involved in a good partnership with Virat Kohli.
Virat Kohli was dismissed in the 40s for the second time in succession.
Rohit Sharma and Hardik Pandya were involved in a useful association that took India closer.
Rohit Sharma equalled the record for the most T20I hundreds, registering his third.
India secured a seven-wicket victory to win the series 2-1, bagging their sixth T20I trophy in a row.